The photo-oxidation effect of palladium phthalocyanine regioisomers in liposomes
Aleksandr Penni – Doctoral Researcher, Tampere University; Alexander Efimov – Adjunct Professor, Tampere University; Nikita Durandin – Docent, Tampere University; Timo Laaksonen – Professor, University of Helsinki
Doctoral Researcher University of Helsinki, Finland
Introduction: Porphyrin derivatives have been investigated for photodynamic therapy (PDT) in which a photosensitizer is exposed to light to generate reactive oxygen species (ROSs).1 ROSs oxidize cellular membranes leading to apoptosis. We have developed palladium phthalocyanine (PdPc) regioisomers called windmill, dragon, and frog having markedly high ROS formation capability. Thus, we investigated if these PdPcs could be encapsulated in liposomes and utilized in PDT. Verteporfin, being in clinical use for PDT (Visudyne®), was used as a control to assess photo-oxidation effect of PdPcs on lipid bilayers.
Learning Objectives:
recognize impact of small substituent-position shifts on utilization of photosensitizers in light-sensitive NPs.
understand a higher ROS generation of photosensitizer improves photo-oxidation, despite of lower encapsulation.
