Protein Crystallization for Drug Delivery Applications
Eid Nassar-Marjia – PhD Student, Chemical Engineering, Technion Israel Institute of Technology; Simran Jindal – PhD Student, Chemical Engineering, Technion Israel Institute of Technology; Shady Farah – Asst. Professor, Chemical Engineering, Technion Israel Institute of Technology
PhD Student Technion - Israel Institute of Technology Haifa, Hefa, Israel
Introduction: In recent years, biopharmaceuticals have grown exponentially as treatments for several health conditions; however, their application faces several limitations, including poor stability and limited delivery options.[1] Protein crystals overcome these challenges by providing stable, high-concentration formulations with controlled release.[2] In this study, we investigate the crystallization of antimicrobial enzymes to develop a delivery system that serves as an active therapeutic protein delivery platform.
Learning Objectives:
Understand the scaled-up crystallization process and how different conditions affect the process.
Explain the enhanced properties of crystals compared to the amorphous form.
Evaluate the potential of protein crystals as an enhanced delivery system for biopharmaceuticals.
