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Skin and Mucosal Delivery (Focus Group – SMD)

A Multi-Format Microneedle Patch Platform for Skin Vaccination

Seung-Ki Baek – CEO, QuadMedicine Inc.

    Poster Presenter(s)

  • JP

    JUNG-HWAN PARK, Ph.D

    Professor
    Gachon University / QuadMedicine Inc.
    Seongnam, Republic of Korea

Introduction:

Microneedle array patches (MAPs) enable needle-free skin vaccination and can leverage solid-state formulations. However, optimal MAP formats differ by payload: some vaccines are best handled as coated layers, others as dry powders, and adjuvants may require independent preparation to preserve activity and enable flexible pairing. A modular MAP system integrating C-MAP, P-MAP, and a dual-patch strategy was developed to address antigen–adjuvant-specific requirements.

Learning Objectives:

  • Describe a modular MAP platform integrating C-MAP, P-MAP, and dual-patch adjuvantation for skin vaccination.
  • Compare coated versus powder-attached MAPs for delivery and stability of protein vaccines and mRNA-LNP vaccines.
  • Demonstrate sequential adjuvant patching to enable modular antigen–adjuvant pairing and enhance immune response.