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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

When carriers are not inert: exploring formulation-dependent immune responses to LNPs in THP-1 cells

Ester Polo – Prof., CiQUS - USC; Beatriz Pelaz – Prof., CiQUS - USC; Pablo del Pino – Prof., CiQUS - USC

    Poster Presenter(s)

  • Mafalda Gonçalves

    MSCA Postdoctoral fellow
    CiQUS - USC
    Santiago de Compostela, Spain

Introduction:

Lipid nanoparticles (LNPs) are increasingly recognized as biologically active systems whose carrier composition can directly influence immune cell responses  [1]. However, the intrinsic immunomodulatory effects of LNP formulations remain incompletely understood, particularly independent of nucleic acid cargo  [2]. This study investigated how ionizable lipid identity and dexamethasone (Dx) incorporation shape immune marker responses in THP-1 cells under basal and pro-inflammatory (M1) conditions.

Learning Objectives:

  • Understand how LNPs are associated with immune marker responses in THP-1 cells.
  • Explain why evaluating carrier-only LNPs is important for isolating formulation-driven effects.
  • Evaluate formulation-dependent trends in immune marker expression following LNP exposure.