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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Adhesive Hydrogel Loaded with mRNA Lipid Nanoparticles for the Treatment of Osteoarthritis

Natividad Gómez Cerezo – associate professor, Complutense University of Madrid; Miguel Manzano García – full professor, Complutense University of Madrid; María Vallet-Regí – professor emerita, Complutense University of Madrid
Introduction:

Osteoarticular diseases are challenging to treat due to the limited regenerative capacity and avascular nature of cartilage, as well as the rapid clearance of intra-articular therapies.[1] Materials science provides promising strategies for localized and sustained drug delivery. For regenerative medicine, materials science and gene therapy hold great potential. [2] But its clinical translation is hindered by poor cellular delivery. Nanoparticles offer a solution to the limitations. [3] This work focuses on the development of a hydrogel platform for efficient intra-articular delivery of nanoparticles to enhance gene transfer to chondrocytes.

Learning Objectives:

  • Upon completion, participant will be able to identify key factors controlling hydrogel adhesion
  • Upon completion, the participant will be able to analyze necessary parameters of LNPs for cartilage treatment
  • Upon completion, the participant will be able to evaluate release kinetics and gene delivery performance.