PhD Candidate University of Illinois at Chicago Chicago, Illinois, United States
Introduction: Group A Streptococcus (GAS) causes skin and soft tissue infections worldwide. The Rgg2/Rgg3 quorum sensing system regulates virulence, biofilm formation, and host adaptation. Targeting quorum sensing reduces pathogenicity without imposing bactericidal pressure. Cyclosporin A inhibits this pathway but suffers from poor aqueous solubility and limited bioavailability. This study develops nanocarrier systems to enhance topical delivery and quorum sensing inhibition.
Learning Objectives:
Evaluate nanocarrier strategies to enhance topical CsA delivery
Analyze formulation effects on quorum sensing inhibition
Explain the rationale for targeting bacterial communication over growth
