Permexa™ C10: An Engineered Sodium Caprate for Improved Flowability and Compressibility in Oral Peptide Tablets

The oral administration of biologics presents significant challenges in pharmaceutical development. Permeation enhancers (PEs) such as sodium caprate (SC) facilitate the oral absorption of low-permeability drugs like peptides by enhancing intestinal uptake. Despite its effectiveness, sodium caprate's suboptimal flow and compression characteristics restrict its application in direct-compression tableting for biologics. Permexa™ is a process-engineered variant of SC, designed to improve flowability and compactibility, thereby enabling more robust tablet production. Evaluations compared peptide tablet formulations with Permexa™ to those made with commercially available SC.