Development and Evaluation of Vitamin E–Functionalized Nanoformulation for Transdermal Drug Delivery

Lobna Hatem – assistant professor, Misr International University; Randa Latif – Professor, Cairo University; Hany Mahmoud – Professor, Misr International University; Mai Tawfik – Asistan Professor, Egyptian Chinese University

Introduction:

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia; studies have suggested that patients with AD also have altered melatonin levels and pineal gland function (1). Melatonin  is a key hormone that may also contribute to the neuroprotective effects associated with sleep. It is synthesized in the pineal gland and exerts effects across both the central nervous system and peripheral organs. (2). Transdermal drug delivery represents a promising alternative to conventional routes of administration. Advantages include release sustainment, avoidance of first-pass metabolism, and reduction in systemic adverse effects (3)