Effect of diluent and binder type on the acetaminophen release from tablets under simulated fasted and fed conditions

Alina Jaroslava Frolova – Laboratory assistant, Riga Stradins University, Faculty of Pharmacy, Leading Research Group; Kirils Kukuls – Laboratory technician, Riga Stradins University, Faculty of Pharmacy, Leading Research Group; Valentyn Mohylyuk – Leading visiting researcher, Riga Stradins University, Faculty of Pharmacy, Leading Research Group

Introduction:

Acetaminophen is an analgesic and antipyretic drug, that is classified as BCS Class III at most clinically relevant doses, characterized by high aqueous solubility and low permeability. Food intake modifies gastric media viscosity, a key factor influencing the release of drugs with low permeability. In gastric media pH, acetaminophen is not ionised (pKa 9.5). Tablet excipients such as diluent and binder can affect disintegration and dissolution time that in turn affect bioavailability of the drug.[1]

This investigation aimed to study the effect of 2 binder types and 3 diluent types on the disintegration and in vitro release of acetaminophen from tablets under simulated fasted and fed conditions.