Professor Seoul National University PyeongChang, Republic of Korea
Introduction: Rapid mucociliary clearance (MCC) severely limits the efficacy of nasal drug and vaccine delivery. Most mucoadhesive strategies rely on spherical nanoparticles, which provide limited surface contact with planar mucosal layers. Here, we propose that a flat, two-dimensional (2D) nanoscale architecture, enabled by polyphenolic adhesion, can resist MCC more effectively. We introduce a tannic acid (TA)–based 2D nanopatch designed to enhance nasal mucoadhesion and mucosal immune activation.
Learning Objectives:
Upon completion, participant will describe limits of nanoparticles and MCC in nasal delivery.
Upon completion, participant will explain tannic acid–mediated assembly and 2D mucoadhesion.
Upon completion, participant will evaluate effects of 2D nanopatches on immunity and IgA induction.
