Improvement of the Bioavailability of Poorly Soluble Drugs via Wet Bead Milling and Fluid Bed Processing - Scale Up

Alexander Schmidt – Area Sales Manager, Willy A. Bachofen AG; Dominik Eugster – Head of Sales & Marketing / Registered Attorney, Willy A. Bachofen AG; Adele Rakotonirina – Junior Business Development Manager, Glatt Pharmaceutical Services GmbH und Co. KG; shuai Shi – Scientist Formulation & Process Development, Glatt Pharmaceutical Services GmbH und Co. KG

Introduction: The bioavailability of many drugs is limited by the poor solubility of the active ingredient. Various formulation strategies have been investigated [1]. Among these, reducing API particle size to the nanometer scale – resulting in API nanoparticle formulations – has demonstrated significant potential by enhancing dissolution rate, saturation solubility, and membrane adhesiveness, improving the bioavailability [2]. Fluid bed processing, provides an effective method for solidifying formulations to create oral dosage forms, and is also applicable to API nanoparticle formulations [4,5].