Introduction: Asthma is a chronic airway disorder marked by persistent inflammation and cytokine dysregulation. While curcumin and hydroxychavicol (Piper betle) show synergistic potential by suppressing NF-kB and ROS cascades, their clinical use is hindered by poor solubility and low bioavailability. This study aims to overcome these biopharmaceutical barriers by developing a lyophilized orodispersible film (ODF) using supramolecular inclusion complexes to enhance sublingual delivery and therapeutic efficacy, providing a dysphagia-compatible platform for rapid-onset asthma symptom management.
Learning Objectives:
Evaluate the synergistic anti-inflammatory effects of curcumin and betel leaf extract in asthma management
Analyze the optimization of orodispersible film formulations using central composite design parameters
Assess lyophilization and complexation impact on phytoconstituent bioavailability
