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Manufacturing and Process Scale-Up

Programmable Release of a Negatively Charged Compound from a 3D-Printed Electroresponsive Drug Delivery System

Abdul Basit – Professor, UCL; Christopher Chapman – lecturer, QMUL; Moe Elbadawi – lecturer, QMUL; Simon Gaisford – Professor, UCL; Rylie Green – Professor, Imperial college london; Mine Orlu – Professor, UCL
Introduction:

Electrically responsive drug delivery systems represent promising approach for achieving precise on-demand drug release in line with the principles of precision medicine [1]. Conductive polymer-based systems, particularly those incorporating poly(3,4-ethylenedioxythiophene):polystyrene sulfonate, enable controlled release through externally applied electrical stimuli [2]. While previous work demonstrated programmable release of positively charged compounds using a 3D-printed electroresponsive platform, the influence of drug charge on release behaviour remain insufficiently explored. This study investigate the electro-responsive release of negatively charged compound.

Learning Objectives:

  • 1. Understand the impact of drug charge on electro-responsive drug release behaviour.
  • 2. Describe the fabrication and characterization of 3D-printed conductive drug delivery systems.
  • 3. Evaluate the potential of electrically controlled platforms for personalized and on-demand therapies.