PhD student University of Parma Parma, Emilia-Romagna, Italy
Introduction: Ketoprofen lysin salt (KLS) is a widely NSAID used for its analgesic and anti-inflammatory efficacy, characterized by high solubility and rapid onset of action1. However, its short biological half-life involves frequent daily dosing, which often leads to plasma concentration fluctuations and potential gastrointestinal issues2. Developing a controlled-release (CR) oral dosage form is therefore essential to maintain steady-state levels3. This study describes design and characterization of matrix tablets to modulate KLS release and improve patient compliance
Learning Objectives:
Describe key formulation strategies for controlled oral delivery of KLS
Evaluate the impact of modified release on KLS pharmacokinetics
