Research Scholar Punjabi University, Patiala, Punjab, India Karnal, Haryana, India
Introduction: Colon-targeted oral drug delivery systems provide significant therapeutic advantages by enabling site-specific drug release while minimizing premature drug degradation and systemic exposure (1). Natural polysaccharides-based carriers are particularly attractive due to their biodegradability and susceptibility to enzymatic degradation by colonic microflora (2,3). Figure 1 shows the classification of natural polysaccharides on the basis of their source. This study focuses on the development and evaluation of a microbial enzyme-triggered polyelectrolyte complexes (PECs) composed of anionic Mimosa pudica gum and cationic chitosan for colon-targeted oral delivery of capecitabine.
Learning Objectives:
Understand the role of polysaccharide-based PECs in colon-targeted oral drug delivery.
Explain the role of colonic microflora in triggering site-specific drug release.
Evaluate microbiome-responsive strategies for colon-targeted oral delivery.
