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Oral Delivery (Focus Group – OrD)

A Manihot esculenta Starch-Based Floating Gastroretentive System for Sustained Oral Delivery of Methotrexate

Emmanuel Omenazu – Graduate student, Department of Pharmaceutics and Pharmaceutical Technology., Usmanu Danfodiyo University Sokoto

    Poster Presenter(s)

  • YO

    Yinka James OYENIYI, n/a

    Professor
    Usmanu Danfodiyo University Sokoto
    Usanmu Danfodiyo University Sokoto, Sokoto, Nigeria

Introduction:

Management of rheumatoid arthritis (RA) with methotrexate (MTX) is limited by poor oral bioavailability, dose-dependent toxicity, and gastrointestinal side effects. This study aimed to formulate and evaluate a methotrexate floating drug delivery system (FDDS) using Manihot esculenta (Cassava) starch as a natural polymer to enhance gastric retention and sustain drug release.

Learning Objectives:

  • Insights on cassava starch floating microspheres: formulation variables and evaluation parameters
  • Provide an understanding of the release kinetics of CS floating microspheres
  • Gastric retention benefits of methotrexate floating microspheres