Impact of phospholipid on nanoparticles’ properties for oral delivery

Kimia Jandaghi Alaee – student, MINT Laboratory, University of Angers; Jerome Bejaud – assistant engineer, MINT Laboratory, University of Angers; Isabelle Verdu – technician, MINT Laboratory, University of Angers; Catherine Guillet – Engineer, PACEM - SFR ICAT, University of Angers; Jéremie RIou – professor, MINT Laboratory, University of Angers; Marie-Claire Venier – professor, MINT Laboratory, University of Angers

Introduction:

Lipid nanocapsules (LNCs)^[1], can be considered as a core-shell hybrid system (liquid oily core and a solid polymer/phospholipid shell.) They  are prepared by a low-energy emulsification process: the phase-inversion temperature method. They have shown promising properties for oral or intravenous delivery. However, despite the promising benefits, most of the studies focus only on monitoring drugs encapsulated in LNC^[2] but ignore the performance of the carrier itself.  Furthermore, the role of phospholipids in the shell is poorly characterised. This work aims to explore the effect of Lipoid®SPC3 on LNCs’ physicochemical properties and biopharmaceutical properties for oral administration