L-Carnosine as a Biocompatible Dipeptide Carrier for Oral Delivery of Poorly Soluble Bosentan Hydrate

Dominik Strojewski – PhD Student, Doctoral School Jagiellonian University Medical College; Michał Duda – Research Assistant, Jagiellonian University; Agnieszka Skórska-Stania – Assistant Professor, Jagiellonian University; Natalia Górska – Assistant Professor, Jagiellonian University; Gniewomir Latacz – Professor, Jagiellonian University Medical College; Maja Kudrycka – Research Assistant, Jagiellonian University Medical College; Florence Danede – Research Assistant, Universite de Lille UMR CNRS; Laurent Paccou – Research Assistant, Universite de Lille UMR CNRS; Yannick Guinet – Professor, Universite de Lille UMR CNRS; Alain Hedoux – Professor, Universite de Lille UMR CNRS; Jean-Francois Willart – Professor, Universite de Lille UMR CNRS

Introduction:

In response to the raising demand for multifunctional excipients (1), preferably of natural origin, that could accelerate the design of patient-friendly enabling formulations, we focus, for the first time, on the functionality of a biocompatible dipeptide, L-carnosine (2). Our goal is to prepare amorphous solid dispersions loaded with a model acidic drug bosentan hydrate (3). The safety of L-carnosine is well-established (4), and therefore; it can be considered as an interesting carrier that may enhance the solubility and oral absorption of bosentan (BOS).