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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Green manufacturing process using spinning disc system for preparation of Acetalated maltodextrin nanoparticles

Marc Schneider – Professor, Biopharmacy and Pharmaceutical Sciences, Saarland University
Introduction:

The increasing demand for nanoparticles-based drug delivery requires the sustainable, greener and scalable manufacturing process [1]. Conventional processes are mostly time consuming, require high energy and mostly require additional solvent removing steps. In addition, scaling up these processes is very difficult [2]. In this work, we present a spinning disc system (SDS) for the preparation of nanoparticles (NP) that overcomes above-mentioned limitations and provides reproducible NP with desired critical quality attributes. Furthermore, applying sustainable polymers like Acetalated Maltodextrin (Ac-MD) to this continuous one - pot process makes the process even greener [3].

Learning Objectives:

  • Comprehend a green process that can continuously produce nanoparticles with controlled quality attributes.
  • Recognize spinning disc system (SDS) that can produce nanoparticles in a very short time with a high yield.
  • Prepare paclitaxel loaded Acetalated maltodextrin nanoparticles with high encapsulation efficiency using SDS.