Multi-target Intestinal Barrier Repair for Gut Inflammation and Gut-Liver Axis–Related Metabolic Diseases
Wen Li – 236 Baidi Road, Nankai District Tianjin, China, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College; Linhua Zhang – 236 Baidi Road, Nankai District Tianjin, China, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College; Guilei Ma – 236 Baidi Road, Nankai District Tianjin, China, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College; Dunwan Zhu – 236 Baidi Road, Nankai District Tianjin, China, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College; Lin Mei – 236 Baidi Road, Nankai District Tianjin, China, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
post-doctoral Institute of Biomedical Engineering, Chinese Academy of Medical Sciences Tianjin, China (People's Republic)
Introduction: Targeting intestinal barrier disruption in IBD and NASH, we developed PGaA Gel, a multifunctional inulin hydrogel co-loaded with MPDA-Ga and L-alanyl-L-glutamine. It repairs the barrier by scavenging ROS, modulating pathogenic microbiota, and promoting mucosal regeneration. In murine models, PGaA Gel effectively alleviated colitis and, by restoring gut integrity, mitigated gut-liver axis dysfunction, significantly reducing liver inflammation and lipid accumulation in NASH. This work offers a holistic therapeutic strategy for IBD and associated metabolic diseases.
Learning Objectives:
Upon completion, participant will be able to explain the synergistic 4-barrier repair mechanism of PGaA Gel.
Upon completion, participant will be able to describe PGaA Gel's therapeutic effects in IBD and NASH models.
Upon completion, participant will be able to identify gut barrier repair as a target for gut-liver axis disorders.
