Postdoc researcher Institut Químic de Sarrià (IQS) Barcelona, Catalonia, Spain
Introduction: Poly(β-amino ester) (pBAE) polymers are among the most promising non-viral vectors for RNA delivery due to their biodegradability and high transfection efficiency. However, their biological performance is highly sensitive to polymer architecture and surface chemistry, often limiting reproducibility and rational optimisation. This study aimed to establish a modular structure–function framework for pBAE-based nanoparticles, enabling predictable control over RNA encapsulation, cellular uptake, and cell-type specificity in lung cancer–relevant models.
Learning Objectives:
Upon completion, participant will be able to describe how click chemistry enables modular pBAE design.
Upon completion, participant will be able to explain structure–function relationships governing RNA delivery.
Upon completion, participant will be able to evaluate how surface functionalisation drives targeting in lung models
