A Powder-Based Microneedle Patch for Stable and Effective Skin Delivery of Clinical mRNA-LNP Vaccines

Jung-Hwan Park – Professor, Gachon University

Poster Presenter(s)

Min-Ju Kwon

student
Gachon University, Republic of Korea

Introduction:

mRNA–lipid nanoparticle (mRNA-LNP) vaccines show high efficacy but suffer from limited thermal stability and unwanted distribution to off-target organs after injection. To address these issues, we developed a powder-attached microneedle patch (P-MAP) that delivers clinically validated mRNA-LNP vaccines through the skin without modifying their original formulation or manufacturing process. We evaluated delivery efficiency, structural integrity, release behavior, and immune responses after skin administration.

Learning Objectives:

Upon completion, participants will be able to describe controlled release of mRNA-LNPs via P-MAP.
Upon completion, participants will be able to compare P-MAP and C-MAP for delivery and release.
Upon completion, participants will be able to assess how release kinetics affect mRNA-LNP stability and immunity.