Formulation scientist F. Hoffmann-La Roche Ltd Basel, Basel-Stadt, Switzerland
Introduction: Salcaprozate sodium (SNAC) is a novel absorption enhancer often used to enable the oral delivery of macromolecules. The material attributes of SNAC remain poorly described in the scientific literature, limiting a rational formulation development, considering the high content often needed to drive the absorption of the drug [1-2]. This study aimed to comprehensively characterize SNAC from different commercial suppliers and to evaluate the impact of its material attributes on tablet manufacturability and release of oligonucleotide from the formulations.
Learning Objectives:
Evaluate the physico-chemical differences between commercial qualities of SNAC.
Understand the limitations in manufacturing SNAC based tablet formulations.
Explain the dissolution behavior of SNAC based tablet formulations containing a macromolecule.
