Single atom-doped MOF upconversion photocatalyst for rheumatoid arthritis therapy
Dowook Ahn – Student, Sungkyunkwan University, School of Pharmacy; Yunkyu Yang – Student, Sungkyunkwan University, School of Pharmacy; Yu Seok Youn – Professor, Sungkyunkwan University, School of Pharmacy
MS/PhD Student Sungkyunkwan university, Republic of Korea
Introduction: Metal organic frameworks (MOFs) are porous and crystalline materials formed from the self-assembly between metal nodes and organic linkers (1). However, MOF-based materials are still in their early stages and further efforts are required to achieve performance in real-world applications (2). Single atom-doped MOF-coated upconversion nanoparticles (UCNPs) incorporating stimulator of interferon genes (STING) antagonist enhances catalytic activity of single atom and inhibits the inflammation pathway, showing strong potential for anti-inflammation and rheumatoid arthritis therapy.
Learning Objectives:
Learn the design principle of combining UCNPs with PCN shells to amplify single atom catalytic activity.
Interpret enzyme-mimicking ROS scavenging mechanisms and their relevance to inflammation control.
Evaluate benefits of combining ROS scavenging with immunomodulation for anti-inflammation therapy.
