Colon-targeted spray-dried nano-in-microparticles with triple action for inflammatory bowel disease.

Andréia Meneguin – Professor, São Paulo State University

Poster Presenter(s)

Vinicius Martinho Borges Cardoso, Mr

PhD Student
São Paulo State University, Sao Paulo, Brazil

Introduction:

Inflammatory bowel disease (IBD) raises colorectal cancer risk and relates to gut microbiota dysbiosis and barrier impairment[1,2]. Mesalazine (MLZ), first-line drug, shows low colonic bioavailability due to rapid metabolism [3]. Complementary therapies like probiotics (PROB) and sodium butyrate (BUT) help restore gut health [4,5]. Colon-selective polymers such as chitosan (CS), retrograded starch (RS), and pectin (P) enable targeted delivery. This study designs a nano-in-microparticle (NMP) system: CS nanoparticles with BUT co-encapsulated in RS and P microparticles containing MLZ and PROB via spray-drying.

Learning Objectives:

Understand the formation process of nano-to-microparticle systems.
Assess the development of drug-loaded polymeric nanoparticles.
Determine the viability of probiotics following spray-drying atomization