Engineering a 3D printed Deployable Oral Device for Localised Peptide Delivery

Susanna Abrahamsen Alami – Science and Innovation Director, AstraZeneca; Cameron Alexander – Professor, University of Nottingham; Morgan Alexander – Professor, University of Nottingham; Jonathan Booth – Principal Scientist, AstraZeneca; Nigel Davies – Senior Principle Scientist, AstraZeneca; Michael Garle – Senior technician, University of Nottingham; Alice Goode – Senior technician, University of Nottingham; Anna Katowska – Senior Research Fellow, University of Nottingham; Wen-Jung Lu – Research Fellow, University of Nottingham; Kyriaki Pafiti – Research Fellow, University of Nottingham; Clive J Roberts – Head of School of Life Sciences, University of Nottingham; Ricky Wildman – Professor, University of Nottingham

Introduction: Oral delivery of peptides is challenging due to enzymatic degradation, low permeability and rapid intestinal transit, resulting in poor and variable bioavailability [1,2]. Advances in additive manufacturing enable mechanically active oral devices with tailored geometry and function [3]. Here, we describe an injection-inspired oral delivery concept based in a swallowable capsule that deploys a 3D printed stent in small intestine for peptide localisation and increase residence time. Device design was supported by mechanical testing of the printed material, and peptide delivery to an ex-vivo ileum model was demonstrated and visualised using OrbiSIMS for label free mass spectrometry analysis