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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Polycaprolactone nanoparticles for encapsulation black pepper extract

Janaina Ataide – Professor, School of Pharmaceutical Sciences, USP/RP; Julia Coco – Research and development, Myralis; Erica dos Santos – PhD candidate, Faculty of Pharmaceutical Sciences UNICAMP; Luiza Silverio – PhD candidate, Faculty of Pharmaceutical Sciences UNICAMP
Introduction:

Black pepper, a fruit widely used as a condiment and in traditional medicine, exhibits antioxidant, antimicrobial, and anti-inflammatory activities. Piperine, its main pungent alkaloid, also has pharmacological and cosmetic properties (1). Nanocarriers are a well-established strategy to enhance the stability, bioavailability, and controlled release of bioactive compounds (2). This research aimed to extract and evaluate black pepper's constituents, followed by encapsulation to assess piperine's release profile and the nanoformulation's stability for pharmaceutical or cosmetic use.

Learning Objectives:

  • Describe the cosmetic and pharmaceutical potential of black pepper extract as a source of bioactive compounds
  • Explain how nanoencapsulation in PCL nanoparticles enables sustained release of piperine
  • Evaluate physicochemical stability and performance of PCL nanoparticles as delivery systems for natural extracts