Ph.D. Student Pohang University of Science and Technology (POSTECH) Pohang-si, Kyongsang-bukto, Republic of Korea
Introduction: Inflammatory bowel disease (IBD) remains a major clinical challenge due to chronic inflammation, oxidative stress, hypoxia, and impaired mucosal barriers in the gastrointestinal tract [1, 2]. Current treatments often suffer from limited efficacy because therapeutic agents are rapidly cleared from the intestine and poorly retained at inflamed sites. Here, we present enzyme-powered nanobot swarms capable of chemical feedback–mediated communication, enabling collective behavior that enhances therapeutic performance in intestinal inflammation (Figure 1).
Learning Objectives:
Understand how chemical feedback communication enables swarm-level behavior in enzyme-powered nanobots.
Assess tandem enzymatic nanobot swarm performance for intestinal navigation and microenvironment modulation.
Evaluate the therapeutic potential of drug-free communicating nanobot swarms for IBD.
