Optimisation of ultrasound-responsive niosomes for localised delivery of chemotherapy

Sachin Thakur – Senior Lecturer, School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland; Zimei Wu – Professor, School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland

Introduction:

Dosing-limiting adverse effects of non-specific chemotherapy continue to pose a major clinical challenge [1]. Ultrasound (US) offers a promising external mechanism to spatially control drug release from nanocarriers at their target site [2]. Niosomes are attractive delivery systems due to their structural stability, compositional flexibility and low manufacturing cost [3]. This study explored the US-responsiveness and blood stability of various niosome compositions.