Skip to main content
CRS 2026 Annual Meeting & Exposition Main banner
Rate ePoster

Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Ethyl oleate-based in situ forming gel for long-term peptide delivery via lamellar phase transition

Tao Gong – China, West China School of Pharmacy, Sichuan University

    Poster Presenter(s)

  • Lu Huang

    Ph.D. Candidate
    West China School of Pharmacy, Sichuan University
    Chengdu, Sichuan, China (People's Republic)

Introduction:

The clinical application of therapeutic peptides is often hampered by their short half-life and the need for frequent injections (1). This study aims to develop a novel, hydrophilic organic solvent-free in situ forming gel (ISG) for sustained peptide delivery. The system utilizes a phospholipid/ethyl oleate (EO) formulation designed to undergo a unique, water-triggered sol-gel transition upon subcutaneous injection, forming a stable depot.

Learning Objectives:

  • Understand the characterization methods of ISG.
  • Describe the water-triggered mechanism of in situ gel formation.
  • Explain the advantages of using ethyl oleate in enhancing peptide stability and local biocompatibility.