Biomimetic platelet-membrane cloaked nanoparticles for cardiovascular diseases
Mariagiulia Spazzapan – Postdoctoral Researcher, Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy; Andrea Colliva – Research Associate, Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy; Serena Zacchigna – Professor, Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy; Hélder A. Santos – Professor, Department of Biomaterials and Biomedical Technology, University Medical Center Groningen (UMCG), Groningen, the Netherlands
Postdoctoral Researcher German International University Cairo, Al Qahirah, Egypt
Introduction: Cardiovascular diseases, such as ischemic heart disease and stroke, are the leading cause of deaths worldwide. Nanotechnology offers many advantages including enhanced permeability and retention into blood vessels, enhanced drug targeting and minimized side effects. Hence, we sought to prepare biomimetic nanoparticles (NPs) as a novel treatment avenue against cardiovascular diseases.
Learning Objectives:
Apply platelet-membrane coating as a technique to prepare injectable biomimetic nanoparticle delivery system.
Understand the effect of platelet-membrane coating of nanoparticles on endothelial cells.
