Advancing transdermal Docetaxel delivery: radiometric evaluation and assessment of an artificial skin model

Helen Cauldbeck – Academic Supervisor, University of Liverpool

Introduction:

Nanoformulation of non-water soluble, lipophilic Docetaxel (DCTX) into solid drug nanoparticles (SDNs) allows the generation of an aqueous dispersion to facilitate its transdermal delivery (TD).¹ To reduce reliance on biological tissue in such TD studies, in vitro skin mimics such as Strat-M, are increasingly used.² However, their ability to predict the permeation of nanoformulated actives within complex formulations remains uncertain. Radioanalytics were used to conduct comparative permeation experiments through Strat-M and human skin to assess the model’s predictive capabilities.