Silk Sericin Nanohydrogel-Encapsulated Biogenic MgO Nanoparticles: Characterization and Anticancer Activity

Kunle Okaiyeto – postdoctoral researcher, University G. d'Annunzio od Chieti and Pescara; Bartosz Klebowski – postdoctoral researcher, Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland; Camilla Elena Di Bella – PhD student, University of G. d'Annunzio of Chieti and Pescara; Angela Maria Dabbicco – master student, University G. d'Annunzio Chieti-Pescara; Joice Maria Joseph – postdoctoral researcher, University G. d'Annunzio of Cheiti-Pescara; Susi Zara – Professor, University of G. d'Annunzio of Cheiti and Pescara; Piera Di Martino – Professor, University of G. d'Annunzio Chieti-Pescara

Introduction:

Melanoma is a lethal skin cancer mainly due to environmental factors associated to UV overexposure. The incidence of melanoma has been significantly influenced by human behavior in recent decades, and a weakened immune system, a high frequency of minor abnormalities, and genetic mutation are additional risk factors for melanoma [1]. With 100,000 new cases and 22,000 fatalities annually, cutaneous melanoma is widely regarded as a serious illness in Europe. Delays in diagnosis and treatment ineffectiveness are the causes of this high death rate [2].