Development and characterisation of topically applied oxygen-loaded hydrogels for chronic wound healing
Sara Hanning – Senior Lecturer, The University of Auckland; Odunayo Mugisho – Senior Research Fellow, The University of Auckland; Sachin Thakur – Senior Lecturer, The University of Auckland
PhD candidate The University of Auckland Auckland, Auckland, New Zealand
Introduction: Chronic wounds are wounds that remain in an inflammatory state 12 weeks after injury (1). The reasons for their development are multifactorial, but outcomes of tissue necrosis, reduced quality of life and potential surgical intervention are common. Current treatment focuses on symptomatic management in the hopes of re-establishing wound healing, often to no avail. Oxygen (O2) supplementation of wounds is in the spotlight given its potential to stabilise the wound microenvironment and promote secondary healing (2). Hydrogel platforms may be a suitable mode of O2 delivery.
Learning Objectives:
Explain the use of oxygen as a candidate for chronic wound management.
Understand the potential of hydrogel formulations as carriers for gas-based therapies.
Determine how different excipients and mixing strategies impact oxygen loading into hydrogels.
