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Skin and Mucosal Delivery (Focus Group – SMD)

Restoring Pro-Healing microRNA-132 Signaling in Chronic Wounds via Nanoparticle Delivery

Ning Xu Landén – Associate Professor, Unit of Dermatology, Department of Medicine, Karolinska Institutet; Bruno Sarmento – Professor, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Universitário de Ciências da Saúde (IUCS – CESPU); Sergiu-Bogdan Catrina – Senior Lecturer/Senior Physician, Department of Molecular Medicine and Surgery, Karolinska Institute, Center for Diabetes, Academic Specialist Center; Georgios A. Sotiriou – Professor, Science for Life Laboratory (SciLifeLab), Department of Chemistry, Stockholm University
Introduction:

Chronic wounds, particularly in diabetic patients, represent a major clinical burden due to impaired healing and prolonged inflammation. MicroRNAs regulate multiple stages of tissue repair by coordinating inflammatory and regenerative pathways.1 miR-132 is strongly induced during normal wound healing and promotes fibroblast migration and tissue regeneration, yet is significantly reduced in diabetic wounds.2,3 Nanomedicine-based delivery strategies offer a promising approach to protect and restore therapeutic microRNA signaling locally, enabling pathway-level modulation of chronic wound healing.

Learning Objectives:

  • Understand the role of microRNA-132-3p in regulating wound healing pathways.
  • Explain how lipid nanoparticles enable effective delivery of therapeutic microRNAs.
  • Assess the potential of RNA-based nanomedicines for chronic wound treatment.