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Manufacturing and Process Scale-Up

Scalable Continuous Manufacturing of Multi-drug Liposomes: Tuning Size and PDI via Post-loading

Diane Burgess, Ph.D. – Distinguished Professor, Pfizer Distinguished Chair in Pharmaceutical Technology, Pharmaceutical Sciences, University of Connecticut

    Poster Presenter(s)

  • Luke Burroughs

    Graduate Student
    University of Connecticut
    Storrs, Connecticut, United States

Introduction:

Continuous manufacturing (CM) offers scalability and parameter optimization often lacking in batch liposome production. This study investigates a complete CM platform to produce multi-drug loaded liposomes (Paclitaxel and Docetaxel) and evaluates the feasibility of post-loading surface modifiers to control particle size and polydispersity index (PDI). The goal is to enable the manufacturing of highly monodisperse, multi-drug formulations with improved translational potential.

Learning Objectives:

  • Describe an end-to-end continuous manufacturing platform with inline PAT for liposome manufacturing
  • Evaluate multidrug loaded chemotherapeutic liposome properties across different particle sizes
  • Assess continuous thermal post-loading as a method for tuning surface engineering and PDI