Dual-Function Sutures: Chlorhexidine and Dexamethasone delivery for Infection and Inflammation Control

Héctor Magaña – Professor and Researcher, AutAutonomous University of Baja California; José Manuel Cornejo-Bravo – Professor and Researcher, Autonomous University of Baja California; Lilia Angélica Hurtado-Ayala – Professor and Researcher, Autonomous University of Baja California; Kenia Palomino-Vizcaino – Professor and Researcher, Autonomous University of Baja California; Giovanni Palomino-Vizcaino – Professor and Researcher, Autonomous University of Baja California; Jonathan V. Lopez-Baena – Professor and Researcher, Autonomous University of Baja California

Introduction:

Surgical site infections (SSIs) are common healthcare-associated infections occurring within 30 days after surgery or up to one year with implants [1]. They increase healthcare costs and are often caused by the patient’s own microbiota [2]. Braided sutures promote bacterial adhesion and increase SSI risk [3]. Antimicrobial-coated sutures reduce early bacterial attachment [4], while balanced inflammation is essential for wound healing [5]. This study aims to develop a dual-drug-eluting suture releasing chlorhexidine and dexamethasone to prevent infection and promote wound repair.