Development and Evaluation of an Emulsion-Based Serum for Dermatitis and Skin Barrier Restoration
Arpana purohit, M. Pharm – Research Scholar, Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar; Sushil Kashaw, Ph.D – Professor, Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar
Professor in Pharmaceutics Dr. Harisingh Gour university, Department of Pharmaceutical Sciences Sagar, Madhya Pradesh, India
Introduction: Dermatitis is a chronic inflammatory skin disorder characterized by erythema, pruritus, and xerosis, primarily resulting from skin barrier dysfunction and immune dysregulation. Conventional topical corticosteroid formulations such as creams and ointments containing betamethasone valerate are effective but often limited by greasy texture, poor spreadability, reduced patient compliance, and adverse effects associated with prolonged use. The present study aimed to develop an emulsion-based serum of betamethasone valerate enriched with skin-nourishing agents to enhance therapeutic efficacy and promote skin barrier restoration.
Learning Objectives:
Understand limitations of conventional topical corticosteroids and need for advanced delivery systems.
Evaluate formulation design, optimization, and characterization for stable emulsion-based serums.
Apply skin barrier enhancement and anti-inflammatory principles to develop improved topical formulations.
