Mannose-conjugated chitosan nanoparticles for delivery moxifloxacin against Mycobacterium tuberculosis

Andréia Bagliotti Meneguin – Professor, Department of Drugs and Medicines, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.; Fernando Pavan – Professor, Department of Biological Sciences, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil

Introduction:

Mycobacterium tuberculosis (MTB) remains a major health threat due to its high lethality and ability to persist within macrophages, limiting antibiotic efficacy. This study designed mannose-conjugated chitosan nanoparticles (NPs) loaded with moxifloxacin to target alveolar macrophages via mannose receptor binding, enhancing cellular uptake, intracellular drug delivery, and anti-MTB activity (1).