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Skin and Mucosal Delivery (Focus Group – SMD)

Thermoresponsive systems containing sericin for topical delivery: DLS and rheological characterization

Gabrielli Furlan – Ph.D. student, Pharmacy, State University of Maringa - UEM; Michael Cook – Professor, Pharmacy, University College London
Introduction:

Sericin is a hydrophilic protein extracted from the cocoons of Bombyx mori, considered industrial waste. It has received increasing attention for its biological activities (i.e., antioxidant, anti-inflammatory, antimicrobial and healing potential). It is used in biomaterials to enhance skin repair and regeneration [1]. However, its instability in aqueous media limits pharmaceutical use. The association of sericin with poloxamer 407 (P407) may be an innovative and efficient strategy for the development of topical formulations with healing action, aiming to obtain functional and stable systems capable of gelling at body temperature.

Learning Objectives:

  • Develop thermoresponsive systems by varying the concentrations of sericin and poloxamer 407.
  • Investigate the structural organization of micellar systems with sericin and the changes in gelling behavior.
  • Understand the effects of sericin and Poloxamer 407 amounts on relevant properties to topical delivery.