From Bitterness to Compliance: Ion-Exchange Resin–Mediated Taste Masking of Famotidine in Chewable Tablets
Harshada Patale – Student, Pharmaceutics, Dr. L.H. Hiranandani College of Pharmacy; Pramod Kolsure – Application Manager, IMCD India Pvt Ltd; Nishant Nirale – Manager, IMCD India Pvt Ltd; Rachana Sarawade – Asst Professor & HOD, Dr. L.H. Hiranandani College of Pharmacy; Chhanda Kapadia – Group Director-Technical Services Pharmaceuticals, IMCD India Pvt Ltd
Laboratory Manager IMCD Deutschland GmbH Cologne, Nordrhein-Westfalen, Germany
Introduction: Patient compliance and palatability are the major challenges in oral drug delivery, particularly in paediatric and geriatric populations, as many potent drugs have an intensely bitter taste that limits patient acceptance. Famotidine, a strong H₂-receptor antagonist, is highly bitter and conventional sweeteners in the marketed formulations often leave an undesirable aftertaste. This study aimed to develop a taste-masked famotidine chewable tablet using ion-exchange resin technology to inhibit drug release in saliva while ensuring effective gastric availability and improved patient acceptability.
Learning Objectives:
To evaluate the effect of drug-to-resin ratio and process parameters on drug loading efficiency.
To assess taste masking efficiency using in vitro release studies and human taste panel evaluation.
To compare the performance of formulated tablets with marketed famotidine tablets.
