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CRS 2026 Annual Meeting & Exposition Main banner

Skin and Mucosal Delivery (Focus Group – SMD)

Optimization of the nebulization parameters for enhanced pulmonary delivery of extracellular vesicles

Morgane Daurat – Engineer, IRMB, Univ. Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France; Jade Berthelot – engineer, ICGM, Univ Montpellier, CNRS, ENSCM, Montpellier, France; Marie Maumus – engineer, IRMB, Univ. Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France; Anne Aubert-Poussel – Professor, ICGM, Univ Montpellier, CNRS, ENSCM, Montpellier, France; Marie Morille – Professor, IRMB, Univ. Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France + Institut universitaire de France (IUF), Paris, France
Introduction:

Extracellular vesicles derived from mesenchymal stem cell (MSC-EVs) have been described to exhibit anti-inflammatory and regenerative properties which make them excellent candidates in the context of lung inflammation. Pulmonary delivery, compared to the systemic one, is a non-invasive, patient friendly way to deliver drugs directly and efficiently to the pulmonary cells1. However, Extracellular Vescicles (EVs) delivery through the pulmonary route is yet a challenge to be addressed.

Learning Objectives:

  • describe how formulation parameters critically impact the recovery of MSC- EVs after pulmonary nebulization.
  • describe how EVs Isolation method critically impact the recovery of MSC- EVs after pulmonary nebulization.