3D bio-scaffold for controlled release of lipid nanoparticles in post-surgical GBM therapy

Edmondo Battista – Associate Professor, Geology and Engineering, University of Chieti - Pescara "G. d'Annunzio"; Shameer Pillarisetti – Post-doctoral fellowship, Pharmacy, University of Chieti - Pescara "G. d'Annunzio"; Paola Palumbo – Associate Professor, Clinical Medicine, Public Health, EEnvironmental and Life Science, University of L'Aquila; Christian Celia – Associate Professor, Pharmacy, University of Chieti - Pescara "G. d'Annunzio"

Introduction:

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, characterized by infiltrative growth and a poor prognosis. Current therapies, which include surgical resection, radiotherapy and chemotherapy (temozolomide) had many drawbacks, which limits the efficacy of therapy. In this scenario, there is a significant improvement of nanotherapeutics that passed across the BBB and remain in specific neuronal area after post-surgical resection. This study aims to develop 3D bio-scaffold embedded with lipid nanocarriers to control release, have specific targeting, decrease side effects, and increase effectiveness after implantation.