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Oral Delivery (Focus Group – OrD)

Polymer-coated sporopollenin exine capsules for colon-targeted Lenvatinib delivery

Hayrettin Tonbul – Assistant Professor, Faculty of Pharmacy, Department of Pharmaceutical Technology, Malatya, Türkiye, Inonu University; Seher Guler – MSc Student, Faculty of Science and Arts, Department of Physics, Malatya, Türkiye, Inonu University; Harun Kaya – Professor, Faculty of Engineering and Natural Sciences, Malatya, Türkiye, Malatya Turgut Ozal University; Funda Ersoy Atalay – Professor, Faculty of Science and Arts, Department of Physics, Malatya, Türkiye, Inonu University
Introduction:

Lenvatinib is a tyrosine kinase inhibitor under clinical investigation for colorectal cancer (1). Oral Lenvatinib delivery to colon could increase local drug availability at the disease site and reduce off-target exposure. Sporopollenin exine capsules (SECs) are robust, biocompatible microcarriers suitable for drug loading and customizable surface coating (2). Lenvatinib-loaded SECs were coated with chitosan or Eudragit RS 100 to enable colon-directed delivery by delaying upper GI release and were evaluated via in vitro release and colorectal cancer cell culture assay.

Learning Objectives:

  • Describe how polymer coatings modulate lenvatinib release from Juglans SECs.
  • Compare Eudragit and chitosan coatings using zeta potential and dissolution data.
  • Interpret Caco-2 cell viability results for empty and drug-loaded SECs.