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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Tailoring Versatile Biopolymer-Lipid Hybrid Nanocarriers toward Multifunctional Cancer Therapeutics

Öznur Safgöl – MsC Student, Biofunctional Nanomaterials Design Laboratory, Institute of Biomedical Engineering, Bogazici University; Damla Kelle – PhD Student, Biofunctional Nanomaterials Design Laboratory, Institute of Biomedical Engineering, Bogazici University

    Poster Presenter(s)

  • Banu Iyisan, PhD

    Associate Professor
    Bogazici University
    Istanbul, Turkey

Introduction:

The development of cancer nanotherapeutics requires significant effort to achieve enhanced clinical outcomes. Nanocarriers must exhibit key properties, including biocompatibility, prolonged circulation time, targeted delivery, and high stability.1 Our strategy to improve these features involves tailoring biopolymers as stabilizers and shell materials to produce versatile hybrid nanocarriers with multiple capabilities.2,3 Here we report the design of albumin-hyaluronic acid (BSA-HA) coated lipid nanocarriers as multifunctional cancer therapeutics using surfactant-free, miniemulsion-templated methods.

Learning Objectives:

  • Demonstrate the role of proteins as stabilizers to replace toxic synthetic surfactants in hybrid nanocarriers
  • Investigate the effect of different lipid core compositions on the formation and performance of hybrid nanocarriers
  • Explore the potential of protein–polysaccharide coated lipid nanoparticles as multifunctional therapeutics