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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Tunable Self-Assembled PETOX-b-P4VP Nanoparticles for Drug Delivery Applications

Roujia Chang – PhD student, Department of Biomaterials and Biomedical Technology, University of Groningen, University Medical Center Groningen; Bryn Monnery – Postdoc, Department of Biomaterials and Biomedical Technology, University of Groningen, University Medical Center Groningen; Inge Zuhorn – Full professor, Department of Biomaterials and Biomedical Technology, University of Groningen, University Medical Center Groningen

    Poster Presenter(s)

  • meng qiao

    PhD candidate
    University of Groningen, University Medical Center Groningen
    groningen, Groningen, Netherlands

Introduction:

Polymeric nanoparticles formed by block copolymer self-assembly are widely explored in controlled drug delivery for their ability to encapsulate hydrophobic drugs and improve cellular delivery (1). Poly(2-ethyl-2-oxazoline) is an emerging PEG alternative with favorable biocompatibility, while poly(4-vinylpyridine) offers pH-responsive and drug-interactive properties (2). However, the influence of block length and assembly strategy on delivery performance remains insufficiently understood. This study investigates PETOX-b-P4VP nanoparticles with different block lengths for anticancer drug delivery.

Learning Objectives:

  • explain how block copolymer design influences nanoparticle size and assembly behavior.
  • evaluate the impact of assembly pathways on nanoparticle properties relevant to drug delivery.
  • assess how nanoparticle formulation alters in vitro cytotoxicity profiles of anticancer drugs.