Doctoral student Saarland University Saarbrücken, Saarland, Germany
Introduction: Biological hydrogels serve as protective barriers in various physiological conditions. Concurrently, invading these bio-barriers in drug delivery has become a major challenge. Elasticity of nanoparticles is an emerging physicochemical property which has proven its importance in modulating to enhance the bio-barrier penetration. However, investigating elasticity-driven penetration behavior across dynamic biological environments remains a complex task [1]. As an initial approach to address this challenge, current work investigates the penetration behavior of elasticity modified nanoparticles across a mucus mimicking hydrogel composed of hydroxyethyl cellulose (HEC).
Learning Objectives:
Compare the penetration efficiency of elasticity modified nanoparticles across varying gel concentrations.
Apply nanoparticle deformability principles to design drug delivery systems to target physiological barriers.
