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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Lipid-Entrapped GLP-1RA Ionic Complexes in Mucoadhesive Bilayer Films: Ex-Vivo Porcine Buccal Mucosal Permeation

Sandeep Karki – Researcher, Univercity college Dublin; David Brayden – Professor, University College Dublin
Introduction:

GLP-1-RAs are challenged by poor oral bioavailability due to physicochemical factors including high hydrophilicity, high molecular weight ( >4 kDa), and susceptibility to gastrointestinal degradation (1). Recent efforts employing a permeation-enhancer led to approval of oral semaglutide (Rybelsus®), although it has an oral bioavailability of less than 1% (2). Ionic complexes and lipid-based particulate are combined strategies to enhance transmucosal flux. Non-covalently bound lipopeptides exhibit enhanced compatibility with lipid-based drug delivery systems (3). We aim to formulate mucoadhesive buccal films with lipid preconcentrate-entrapped ionic complexes of GLP-1RA

Learning Objectives:

  • Can the composition of preconcentrate impact GLP-1RA entrapment through screening different oils and surfactants?
  • Can ionic complexes along with pre-concentrate loaded into buccal films demonstrate ex-vivo permeation of GLP-1RA?