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Skin and Mucosal Delivery (Focus Group – SMD)

Transdermal administration of vitamin D through innovative hybrid nanoparticles

MJ Alvarez-Figueroa – Professor, Pontificia Universidad Católica de Chile; J Serer – student, Pontificia Universidad Católica de Chile; A Alegria-gallardo – student, Pontificia Universidad Católica de Chile; A Vergara-Aranda – Student, Pontificia Universidad Católica de Chile
Introduction:

Vitamin D (VD) deficiency is a public health problem. Worldwide, it has been reported that more than one billion people may have a deficiency of this hormone. VD is essential for multiple biological processes; its deficiency is linked to rickets, osteomalacia, among others1.

The most common strategy to address this problem has been the incorporation of VD into multivitamins, or its direct administration in tablets, capsules, or solutions. It is always administered orally. However, these methods of administration have not been as successful as expected due to non-compliance with therapy and because they are not effective for patients with absorption problems or digestive issues.

Learning Objectives:

  • Evaluate the effectiveness of nanoencapsulated VD delivery based on ex vivo skin permeation and retention studies
  • Analyze the physicochemical characterization and encapsulation of hybrid nanoparticles designed for VD delivery.
  • Understand the public health relevance of VD deficiency and the limitations of oral supplementation strategies