Customized Enteric Capsules Enabling High-Load Sodium Caprate Formulations for Oral Delivery of Large Molecules

Marine Agisson – Scientist, Innovaform Accelerator, Capsugel France SAS; Serena Corsi – Scientist, Innovaform Accelerator, Capsugel France SAS; Céline Kientz – Formulation Technician, Innovaform Accelerator, Capsugel France SAS; Delphine Nombret – Manager, Customized Capsules, Innovaform Accelerator, Capsugel France SAS; Vincent Jannin, PhD – Director, R&D, Innovaform Accelerator, Capsugel France SAS

Introduction: Oral delivery of emerging drug modalities such as peptides, PROTACs, and siRNA is hindered by low intestinal permeability and instability in the GI tract, leading to parenteral administration and poor adherence. Enteric Capsugel® Enprotect® capsules enable targeted intestinal release^1-3. Combined with permeation enhancers such as sodium caprate (C10), they could offer a scalable approach to improve oral bioavailability. This study aims to develop a scalable C10-based formulation and design a customized enteric capsule with preserved enteric performance with high C10 loading.